ABSTRACT
Além dos princípios básicos de cirurgia e controle microbiano empregados normalmente na tentativa de diminuir a contaminação no ato cirúrgico, o uso de antibióticos sistêmicos em implantodontia é amplamente difundido por todo o mundo, apesar de grande debate na literatura. Assim, o objetivo deste trabalho foi revisar a literatura a respeito da eficácia dos antibióticos sistêmicos em diminuir falhas de implantes dentais em pacientes saudáveis, além de buscar definição sobre o medicamento mais indicado, bem como sua dose e momento de administração ideais. As evidências científicas a respeito do uso de antibióticos sistêmicos ou não para diminuição das falhas de implantes dentais em pacientes saudáveis são limitadas, porém parece que a administração de uma única dose de 2g de amoxicilina uma hora antes da cirurgia é suficientemente eficaz. De toda maneira, mais estudos com métodos padronizados são necessários para uma completa elucidação do assunto, sendo a indicação dos antibióticos ainda uma escolha de cada clínico, com base nos possíveis benefícios e riscos(AU)
In addition to the basic principles of surgery and microbial control normally employed in an attempt to reduce contamination in the surgical procedures, the use of systemic antibiotics in Implantology is widely accepted worldwide, despite a lot of controversial information in the literature. Therefore, the aim of this study was to carry out a literature review on the effectiveness of systemic antibiotics in reducing dental implant failures in healthy patients, as well as to determine the most appropriate drug, its dosage, and administration time. Scientific evidence regarding the use (or not) of systemic antibiotics to reduce dental implant failures in healthy patients is limited, but it appears that a single dose of 2g of amoxicillin an hour before surgery is sufficiently effective. Anyway, more studies with standardized methods are necessary for a complete definition on the subject. The antibiotic use is still a choice of each clinician, based on its possible benefits and risks(AU)
Subject(s)
Dental Implants , Anti-Bacterial Agents , OsseointegrationABSTRACT
The purpose of the present study was to investigate if diclofenac administration interferes with the time course of alveolar wound healing in rats. Forty-two Wistar rats were used, 21 rats received 10 mg/kg/day of diclofenac one day before and 4 days after extraction of the right maxillary incisors and 21 rats received saline. The animals were sacrificed 7, 14 and 21 days after tooth extraction. Progressive new bone formation and a decrease in the volume fraction of blood clot and connective tissue from 1 to 3 weeks after tooth extraction was quantified using the histometric point-counting method. Diclofenac treatment caused a significant delay in new bone formation in association with an impairment of blood clot remission/organization.
Subject(s)
Animals , Male , Rats , Anti-Inflammatory Agents, Non-Steroidal , Diclofenac , Tooth Extraction , Tooth Socket , Alveolar Process , Anti-Inflammatory Agents, Non-Steroidal , Capillaries , Wound Healing/drug effects , Blood Coagulation/drug effects , Connective Tissue , Diclofenac , Fibroblasts , Injections, Intraperitoneal , Osteogenesis/drug effects , Rats, Wistar , Statistics, Nonparametric , Granulation Tissue/drug effects , Granulation Tissue/pathology , Time Factors , Tooth SocketABSTRACT
A administração endovenosa de sulfato de cobre (4mg/kg de peso) a ratas grávidas, provocou diminuição significativa dos pesos do feto e da placenta e do comprimento do cordão umbilical